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Monday, May 18, 2020 | History

2 edition of metabolism and hepatotoxicity of N-Methylformamide. found in the catalog.

metabolism and hepatotoxicity of N-Methylformamide.

Paul Gerard Pearson

metabolism and hepatotoxicity of N-Methylformamide.

by Paul Gerard Pearson

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  • 26 Currently reading

Published by University of Aston. Department of Pharmaceutical Sciences in Birmingham .
Written in English


Edition Notes

Thesis (PhD) - University of Aston in Birmingham, 1985.

ID Numbers
Open LibraryOL13776529M

As a result, biological monitoring has been extensively used in the assessment of the absorbed amounts in occupa tionally exposed populations. The metabolite most often analysed is N-methylformamide (NMF), and several GC methods exist (Ikeda, ). Using nitrogen-sensitive detection, the limit of detection is mg/litre. A sample of N-methylformamide was purchased from Sigma-Aldrich and used without further purification. The experime ntal investigation of the absorption spectrum of N-methylformamide was carried out over the frequency range 45– GHz using two microwave spectrometers. The first one is .

Acute toxicity - oral Reason for no classification: data lacking Acute toxicity - dermal Hazard category: Acute Tox. 4 Hazard statement: H Harmful in contact with skin. Background. A veterinary euthanasia drug containing embutramide, mebezonium, tetracaine, and dimethylformamide (DMF; T® or Tanax®) may cause serious manifestations or even fatalities after self-poisoning. Immediate toxicity is mainly due to a general anesthetic and due to a neuromuscular blocking agent, while delayed hepatotoxicity seems related to the solvent by: 8.

The base excision repair (BER) pathway is regarded as a very important pathway involved in repairing ROS-induced DNA damage [12,13].Many proteins are involved in BER, however, the roles of human 8-oxoguanine DNA glycosylase (hOGG1), X-ray repair cross-complementing group 1 (XRCC1) and apurinic/apyrimidinic endonuclease-1 (APE1) have been well studied. hOGG1 is a protein that Cited by: 6. Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF.


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Metabolism and hepatotoxicity of N-Methylformamide by Paul Gerard Pearson Download PDF EPUB FB2

N-methylformamide (NMF) produced dose-dependent zone 3 haemorrhagic necrosis in mice; the threshold dose was – mg/kg. In rats a dose of mg/kg caused hepatic damage in some animals and slight elevations of plasma transaminases.

A species difference in susceptibility to NMF-induced hepatotoxicity is clearly indicated. NMF depleted liver non-protein sulphydryl (NPSH) in Cited by: 6. N-Methylformamide is a water-soluble organic an adjuvant antineoplastic agent, N-methylformamide depletes cellular glutathione, a key molecule involved in the antioxidation of reactive oxygen species (ROS) and other free radicals, thereby enhancing ionizing radiation-induced DNA cross-linking in and terminal differentiation of tumor cells.

The metabolism and hepatotoxicity ofN,N-dimethylformamide (DMF) and two of its metabolites,N-hydroxymethyl-N-methylformamide (HMMF) andN-methylformamide (NMF) were evaluated over a 4-day period in rats.

DMF toxicity was dose dependent and delayed toxicity after the administration of a high DMF dose ( mmol/kg) in comparison to a lower dose ( mmol/kg) was by: Chem.-Biol. Interactions, 45 () Elsevier Scientific Publishers Ireland Ltd. Short Communication STUDIES OF THE METABOLISM OF DIMETHYLFORMAMIDE IN MICE CHARLES BRINDLEY, ANDREAS GESCHER* and DAVID ROSS Cancer Research Campaign Experimental Chemotherapy Research Group, Department of Pharmacy, University of Aston in Birmingham, Cited by: N-methylformamide and N-ethylformamide were equitoxic to the TLX5 lymphoma in vitro.

Formamide was found as a metabolite in the plasma and urine of animals given N-methylformamide and N-ethylformamide, but excretion profiles do not support the hypothesis that formamide is an active antitumour species formed from by: N-Methylformamide (NMF) is a colorless, nearly odorless, organic compound with molecular formula CH 3 NHCHO, which is a liquid at room temperature.

NMF is mainly used as a reagent in various organic syntheses with limited applications as a highly polar solvent. NMF is closely related to other formamides, notably formamide and dimethylformamide (DMF).). However, industrial use and production Beilstein Reference:   S-(N-Methylcarbamoyl)-N-acetylcysteine: a urinary metabolite of the hepatotoxic experimental antitumour agent N-methylformamide (NSC ) in mouse, rat and man.

Kestell P, Gledhill AP, Threadgill MD, Gescher by: Metabolism of the solvents N,N-dimethylformamide (DMF) and N-methylformamide (MF) results in the formation of N-methylcarbamoyl adducts at the N-terminal valine and lysine in blood protein globin, of which the lysine adduct has so far only been reported in rats given high doses of both solvents [Mráz, J., Šimek, P., Chvalová, D., Nohová, H., Šmigolová, P., Cited by:   The metabolism of DMF begins with its oxidation to N-hydroxymethyl-N- methylformamide (HMMF) by cytochrome CYP2E1 (Mráz and Turecek,Figure 1A).HMMF further breaks down to form N-methylformamide (NMF), which in turn is oxidized to a reactive intermediate most likely methyl isocyanate (MIC) (Threadgill et al., ).MIC can rapidly bind to endogenous nucleophilic sites, Cited by: 8.

The metabolism and hepatotoxicity of N,N-dimethylformamide (DMF) and two of its metabolites, N-hydroxymethyl-N-methylformamide (HMMF) and N-methylformamide (NMF) were evaluated over a.

Temperature (K) A B C Reference Comment; - Heinrich, Ilavsky, et al.,2: Coefficents calculated by NIST from author's data.

The hepatotoxicity and metabolism of the following close analogs of the hepatotoxic antitumor agent N-methylformamide (NMF) were investigated in CBA/CA mice: N-ethylformamide (NEF.

Other names: Methylformamide; Monomethylformamide; N-Methylformamide; HCONHCH3; EK ; NSC ; X ; N-Monomethylformamide Permanent link for this species.

Use this link for bookmarking this species for future reference. 1 N,N-Dimethylformamide 1. Acute Exposure Guideline Levels. PREFACE. Under the authority of the Federal Advisory Committee Act (FACA) P.L. ofthe National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee) has been established to identify, review, and interpret relevant toxicologic and other scientific data and develop AEGLs for.

We report chemical routes for the synthesis of both nanocrystals and bulk crystals of methylammonium (MA) lead halide perovskites employing N-methylformamide (NMF) as a source of MA ions.

Colloidal nanocrystals were prepared by a transamidation reaction between NMF and an alkyl amine (oleylamine). The nanocrystals showed photoluminescence quantum yields reaching 74% for MAPbBr3 and 60% Cited by: The metabolism of dimethylformamide (see Figure 1) has already been described in detail in the MAK documentation.

The metabolites of dimethylformamide in urine are N-hydroxymethyl-N-methylformamide (HMMF), N-methylformamide (NMF), N-hydroxymethylformamide and formamide (FA). Metabolism of TTX derivatives was studied at 37 °C in m phosphate buffer (pH ) with μ m P from liver microsomes of human or rat treated with various inducers using μ m substrate and an NADPH‐generating system ( m m NADP, m m Glc6P and IU Glc6P dehydrogenase).

The incubation was stopped at the indicated times Cited by: 4. N-METHYLFORMAMIDE is incompatible with benzene sulfonyl chloride.

It is also incompatible with strong oxidizing agents, acids, bases and acid chlorides. It may react with chlorine, bromine, nitrates, nitric acid, triethylaluminum, potassium permanganate, chromic acid, chromic anhydride, chromium trioxide, borohydrides, hydrides, thionyl.

This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, inthe second at the University of Surrey in the United Kingdom, in and the.

N-methylformamide 2. Sodium metal ( g, 60 mmol) was dissolved in mL of anhydrous methanol under gentle reflux. To this solution of sodium methoxide, first mL (60 mmol) of methyl formate was added and then g (59 mmol) of methylammonium chloride under cooling with and ice bath.

The solution was stirred overnight at room temperature. The presence or absence of extrahepatic metabolism did not affect either the estimation of hepatic Vmax and Km or the predicted dose metrics. The proportion of liver metabolism estimated for the lung and kidney was quite small, and %, respectively, based on the microsomal studies.CID | C3H3NO2 | CID - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities.The photochemistry of N‐methylformamide (MF) is elucidated by investigating its photodissociation products generated by UV irradiation ( nm) in an argon matrix (10 K).We find that, starting from trans‐MF, prolonged irradiation produces cis‐MF, CH 3 NH 2 and CO fragments as major products.

Another photoproduct is identified as methylformimidic acid (FIA).